Cardiac Troponin

for Earlier Diagnosis of Myocardial Infarctions

High-Sensitivity Troponin I is the latest addition to Siemens Healthineers’ comprehensive cardiac menu to assist clinicians with the diagnosis and treatment of chest pain patients. Designed to aid in diagnosing acute myocardial infarctions (AMI) through the quantitative measurement of cardiac troponin I in serum or plasma, high-sensitivity troponin plays a critical role in the timely diagnosis of AMI, or heart attacks.

High-sensitivity Troponin I* is now available on the Atellica® IM Analyzer, ADVIA Centaur®Immunoassay System, Dimension® EXL™ and Dimension Vista® Integrated Systems.

Offers improved cardiac patient care with a high-sensitivity troponin assay that meets current guideline recommnedations^1-3
Allows you to measure slight, yet critical, changes between serial troponin I values, giving you confidence in patient results at the low end of the assay range.
Delivers reliable results from proven, trusted technology coupled with three new monoclonal antibodies.

Compared to traditional troponin assays, the Siemens Healthineers Atellica IM, ADVIA Centaur, Dimension EXL and Dimension Vista TNIH assays are able to detect lower levels of troponin and smaller changes to a patient’s troponin levels, which may be an early indication of AMI. This design affords clinicians greater confidence in patient results at the low end of the assay range by delivering precision that provides the ability to measure slight, yet critical, changes between serial troponin I values.

Precision at the low end is important to minimize analytic variation that could confuse a clinician’s assessment of a clinically significant change. With this data in hand, clinicians have the ability to more quickly diagnose and treat patients with suspected AMI, in some cases in as little as one to three hours.

Download the new white paper provides performance data on the ADVIA Centaur High-Sensitivity Troponin I assay 0.3 MB

Assay Specifications

Atellica IM High-Sensitivity Troponin I Assay*

Sample Type	Serum, lithium heparin plasma
Sample Volume	100 µL
Assay Range	2.51 - 25,000.00 pg/mL
Time to First Result	10 minutes
On-board Stability	31 days
Calibration Interval	47 days
LoB	0.58 pg/mL
LoD	1.27 pg/mL
LoQ	2.51 pg/mL

Dimension EXL High-Sensitivity Troponin I Assay*

Sample Type	Human serum, plasma (lithium heparin)
Sample Volume	10 µL
Assay Range	4.0 - 25,000.00 pg/mL (ng/L)
Time to First Result	10 minutes
Throughput	Up to 200 tests/hour
On-board Stability	7 days open well 30 days onboard unpunctured
LoB	1.1 pg/mL (ng/L)
LoD	2.7 pg/mL (ng/L)
LoQ (20% CV)	4.0 pg/mL (ng/L)
LoQ (10% CV)	12.0 pg/mL (ng/L)
99th percentile (n = 2010)	Combined: 60.4 pg/mL (ng/L)^† Male: 76.2 pg/mL (ng/L) Female: 51.4 pg/mL (ng/L)

^†99th percentile value determined using combined gender data and lithium heparin sample type.

Dimension Vista High-Sensitivity Troponin I Assay*

Sample Type	Human serum, plasma (lithium heparin)
Sample Volume	10 µL
Assay Range	3.0 - 25,000.00 pg/mL (ng/L)
Time to First Result	10 minutes
Throughput	Up to 200 tests/hour
On-board Stability	7 days open well 30 days onboard unpunctured
LoB	1.0 pg/mL (ng/L)
LoD	2.0 pg/mL (ng/L)
LoQ (20% CV)	3.0 pg/mL (ng/L)
LoQ (10% CV)	10.0 pg/mL (ng/L)
99th percentile (n = 2010)	Combined: 58.9 pg/mL (ng/L)^‡ Male: 78.5 pg/mL (ng/L) Female: 53.7 pg/mL (ng/L)

^‡99th percentile value determined using combined gender data and lithium heparin sample type.

ADVIA Centaur High-Sensitivity Troponin I Assay*

Sample Type	Human serum, plasma (lithium heparin)
Sample Volume	100 µL
Assay Range	2.50 – 25,000.00 pg/mL (ng/L)
Time to First Result	XP/XPT: 18 minutes
Throughput	Up to 240 tests/hour
On-board Stability	28 days
Calibration Interval	14 days
LoB	0.90 pg/mL (ng/L)
LoD	2.21 pg/mL (ng/L)
LoQ (20% CV)	2.50 pg/mL (ng/L)
LoQ (10% CV)	4.50 pg/mL (ng/L)
99th Percentile	47.34 ng/L (pg/mL)

Cardiac Menu

	ADVIA Centaur® Systems	Atellica® Solution	Dimension® EXL™ Systems	Dimension Vista® Systems	IMMULITE® Systems	Stratus® CS Systems
BNP	√	√		√
CKMB Mass	√	√	√	√	√	√
CKMB Isoenzyme			√	√
D-Dimer					√	√
Galectin-3	√*
High-Sensitivity CRP			√	√	√	√
High-Sensitivity Troponin I¹	√^†	√^†	√^†	√^†
Myoglobin	√	√	√	√	√	√
NT^-proBNP	√^†	√^†	√	√		√
Tnl-Ultra™	√^ǂ	√^†
Troponin I			√^ǂ	√^ǂ	√	√^ǂ

*Under development. Not commercially available. Future availability cannot be guaranteed.
^† Not available for sale in the U.S.
^ǂGuideline-acceptable
1. Available on the ADVIA Centaur XP and XPT Systems only

The products featured here may not be commercially available in all countries. Due to regulatory restrictions, their future availability cannot be guaranteed. Please contact your local Siemens Healthineers representative for further details.

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Guideline-Acceptable Troponin I

* High-sensitivity troponin I is not currently available for sale in the U.S.