Adenosine myocardial stress perfusion using SOMATOM Definition Flash

SOMATOM Definition Flash Scanning

Gudrun Feuchtner1 , Robert Goetti1, Andrè Plass2, Monika Wieser2, Christophe Wyss3, Fernando Vega-Higuera4, Hans Scheffel1, Michael Fischer1, Hatem Alkadhi1, Sebastian Leschka1 |  2010-04-12

1Institute of Diagnostic Radiology; 2Clinic of Cardiovascular Surgery, 3Cardiology Division, University Hospital, Zürich; 2Radiology Department, Innsbruck Medical University; 4Business Unit CT, Siemens Healthcare, Forchheim, Germany.



A 51-year-old male with atypical chest pain and intermediate coronary risk profile (cigarette smoking and hypercholesterolemia) underwent coronary 128-slice Dual Source CT angiography, including adenosine myocardial stress-perfusion.


High-pitch CT angiography showed severely calcified left coronary artery (Fig. 1) with significant stenosis, and bare metal stent in the RCA (Fig. 2) with limited in-stent lumen visibility, thus in-stent restenosis could not be excluded.

Adenosine CT stress perfusion showed a reversible myocardial perfusion defect indicating ischemia anteroseptal at midventricular level (Fig. 3) corresponding to LAD stenosis. No defect was found inferior at RCA vascular territory. Invasive angiography confirmed a significant 90% stenosis at mid LAD and a patent RCA bare-metal stent.

Total radiation dose was 2.2 mSv for adenosine stress and rest CT scans using high-pitch Flash mode at 3.4 pitch factor, the delay between both scans was 5 minutes. Scan time was 0.44 s for each study, tube settings were 100kV and 320 mAs, gantry rotation time was 0.28 s.


Adenosine stress-perfusion is feasible for detection of reversible myocardial ischemia with comprehensive evaluation of coronary arteries. CT perfusion is helpful to improve accuracy of coronary CT angiography, especially in cases of severe coronary calcification or limited in-stent lumen visibility.

Examination Protocol

Scanner SOMATOM Definition Flash
Scan area Heart Perfusion CTA
Scan length 135 mm
Scan direction Cranio-Caudal
Scan time 0.44 s
Tube voltage 100/100
Tube current 320 mAs/rot
Dose modulation CARE Dose 4D
CTDIvol 3.09 mGy
Dose 2.2 mSv
Rotation time 0.28 s
Slice collimation 64 x 0.6 mm
Pitch 3.4
Slice collimation 128x0.6 mm
Slice width 0.75 mm
Reconstruction increment 0.4
Reconstruction kernel B26f
Volume 80 ml
Flow rate 5 ml/s
Start delay 10 s

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